First - check if you have the space for the bigger Topo mat. Most people find that it's bigger than they expected.
If you can fit the bigger mat and you have the budget - go for it!
Unless... you're 5'4" or shorter and you don't want to get too wide with your stance. Then grab Topo Mini instead.
One last consideration. If you plan on moving your mat around to different desks in your home or office, Topo Mini weighs half as much as Topo (4lbs vs 8lbs) and is definitely easier to carry around.
Happy Standing!